Peptides

The hottest, newest corner of longevity. 40 peptides, from BPC-157 to the GLP-1s, with the science, the regulatory reality, and zero sourcing tips.

Metabolic & GLP-1 Peptides

Treatment	Evidence	The honest take
5-Amino-1MQ	Mixed / Early	5-Amino-1MQ rides two of longevity's favorite themes, fat loss and NAD+, on the strength of a clever mechanism and promising mouse studies. But it is unapp
AOD-9604	Thin / Hype	AOD-9604 is a great example of a peptide whose marketing outran its evidence: it failed as a weight-loss drug in humans and has no longevity data behind it
MOTS-c	Mixed / Early	MOTS-c is one of the more scientifically intriguing longevity peptides, with a real mitochondrial story and solid animal data. But human evidence is barely
Retatrutide	Mixed / Early	Retatrutide is the most exciting early-stage entry in the GLP-1 story, with eye-catching weight-loss numbers, but it is unapproved and unproven. Treat any
Semaglutide	Mixed / Early	Semaglutide is one of the most effective metabolic medicines ever approved, with real data behind weight, blood sugar, and heart outcomes. As a longevity t
Tirzepatide	Mixed / Early	Tirzepatide is, by the numbers, the most potent approved GLP-1-class medicine for weight and blood sugar to date. Its longevity benefits are biologically p

Healing & Recovery

Treatment	Evidence	The honest take
ARA-290	Mixed / Early	ARA-290 is one of the few peptides here with genuine human trial data and a thoughtful design, which earns it real scientific respect. But it is still earl
BPC-157	Mixed / Early	BPC-157 has some of the more intriguing animal data in the peptide world, which is why the buzz is real. But intriguing in rats is not proven in people, an
GHK-Cu (Copper Peptides)	Mixed / Early	As a topical skin peptide, GHK-Cu is one of the better-supported options in this section and a reasonable thing to be curious about. As an injectable longe
KPV	Mixed / Early	KPV has a genuinely sensible anti-inflammatory rationale and a clean reputation among enthusiasts, which makes it one of the more intriguing options here.
Larazotide	Mixed / Early	Larazotide is the most thoroughly tested peptide in this section, which is a point in its favor, but its biggest trial came up short and it remains unappro
TB-500 (Thymosin Beta-4)	Mixed / Early	TB-500 borrows credibility from a genuinely interesting natural protein, but the product people actually inject has almost no human evidence behind it and

Brain & Cognition

Treatment	Evidence	The honest take
Cerebrolysin	Mixed / Early	Cerebrolysin is the most clinically established item in this part, a real, approved medicine in several countries with genuine (if inconsistent) trial data
Dihexa	Thin / Hype	Dihexa is fascinating on paper and genuinely striking in animals, but it sits squarely in the realm of unproven experimental science. The human evidence is
Noopept	Mixed / Early	Noopept is the most popular compound in this part, and it has a plausible mechanism plus encouraging animal data, but its reputation outruns its human evid
Selank	Mixed / Early	Selank is an intriguing, mechanistically reasonable anti-anxiety peptide with a real history of Russian clinical study, but the high-quality, independent h
Semax	Mixed / Early	Semax is one of the more credible peptides in the nootropic world, with a real mechanism and a long history of clinical use in one country. But "credible"

Growth-Hormone Secretagogues

Treatment	Evidence	The honest take
CJC-1295	Mixed / Early	CJC-1295 is a credible growth-hormone-raising peptide with thin human-benefit evidence and no long-term safety data, and it is not FDA-approved. The long-a
GHRP-2	Mixed / Early	GHRP-2 is a potent, cheap secretagogue with genuine human pharmacology, it's even been used to test pituitary function, but no long-term human-benefit or s
GHRP-6	Mixed / Early	GHRP-6 is a cheap, historically significant secretagogue that reliably releases growth hormone and reliably makes you ravenous, but it has no human-outcome
Ipamorelin	Mixed / Early	Ipamorelin is a real secretagogue with a clean reputation but a near-empty evidence cupboard for actual benefits. It is not FDA-approved, the long-term saf
MK-677 (Ibutamoren)	Mixed / Early	MK-677 is the convenient, needle-free, orally active secretagogue, and it does durably raise growth hormone and IGF-1 in humans. But it's not a peptide, no
Sermorelin	Promising	Sermorelin is the most legitimate member of this group, a former approved drug with real human history that genuinely raises growth hormone. But the eviden
Tesamorelin	Mixed / Early	Tesamorelin is the evidence standout of this group, genuinely FDA-approved with real trial data, but only for one specific condition, not for general anti-

Vitality, Sex & Sleep

Treatment	Evidence	The honest take
DSIP (Delta Sleep-Inducing Peptide)	Thin / Hype	DSIP has an enticing name and a long research history, but remarkably little human evidence that it actually delivers better sleep. It remains a research-o
Gonadorelin	Promising	Gonadorelin is a legitimate, prescription hormone-signaling peptide with established medical uses and a sensible rationale for preserving fertility during
Kisspeptin	Mixed / Early	Kisspeptin is real, important biology and a genuinely promising tool in fertility research, but its use as a libido or hormone booster is still early and u
Melanotan II	Thin / Hype	Melanotan II tans skin, but it is unapproved, unregulated, and linked in case reports to alarming mole changes and possible melanoma. The cosmetic upside d
PT-141 (Bremelanotide)	Promising	Bremelanotide is a genuine, FDA-approved prescription option for distressing low sexual desire in premenopausal women, with real but modest trial-backed be

Immune, Gut & Cellular Aging

Treatment	Evidence	The honest take
Epitalon	Thin / Hype	Epitalon makes some of the boldest anti-aging promises in this book on some of the thinnest independent evidence. The mechanism is interesting and the mark
Humanin	Mixed / Early	Humanin is one of the more scientifically credible molecules in this section, a natural peptide genuinely linked to healthy aging. But credibility as a mar
LL-37	Mixed / Early	LL-37 is fascinating biology with almost no human-outcome data and a worrying tendency to cut both ways. For longevity it is speculative at best.
Pinealon	Thin / Hype	Pinealon is an intriguing lab-and-animal story sold as a brain-aging solution it has not earned. Without independent human evidence, it sits firmly in the
Thymalin	Mixed / Early	Thymalin pairs a sensible immune-aging rationale with eye-catching but unverified survival claims from a narrow research base. It is more plausible than th
Thymosin Alpha-1	Promising	Thymosin Alpha-1 is among the more legitimate peptides in this section, with genuine overseas clinical use and a sensible mechanism. But its longevity repu

The Frontier (Research-Only)

Treatment	Evidence	The honest take
Follistatin (gene and peptide approaches)	Thin / Hype	Follistatin is one of the most overhyped, under-tested ideas in the longevity fringe. The muscle pictures are seductive; the human evidence is close to zer
Hexarelin	Thin / Hype	Hexarelin reliably triggers a short-term growth-hormone bump, and that's about the limit of what's proven. The effect fades, the longevity rationale is sha
IGF-1 LR3	Thin / Hype	IGF-1 LR3 is a vivid example of a longevity fad that may run against longevity science. The cancer-growth concern alone is enough to give serious pause, an
NAD+ peptide and injectable therapies	Mixed / Early	The NAD+ story rests on real science, but the expensive IV and injectable versions get ahead of the human evidence, and the "instant glow" is easy to overs
SS-31 (Elamipretide)	Mixed / Early	SS-31 is the most scientifically serious peptide in this section, with a credible mechanism and real human trials, but those trials are mixed, and none sup

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